GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs1056667 | 1 | rs9986382 | chr6:26550619 | ZNF322B | chr9:99957633-99961910:- | 0.57 | 11.02 | 2.67E-25 | Educational attainment |
| THCA | trans | rs853679 | 1 | rs9986596 | chr6:28219661 | BTN3A2 | chr6:26365398-26378546:+ | -0.54 | -10.31 | 1.17E-22 | Depression |
| THYM | cis | rs11723261 | 1 | rs10005733 | chr4:292001 | ZNF718 | chr4:53272-156488:+ | 0.54 | 6.46 | 4.44E-9 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs4974559 | 1 | rs10006789 | chr4:1330333 | CRIPAK | chr4:1385340-1389782:+ | 0.76 | 6.54 | 3.04E-9 | Systolic blood pressure |
| THYM | cis | rs2273 | 1 | rs10008757 | chr4:76903036 | NAAA | chr4:76831809-76862166:- | -0.46 | -4.92 | 3.56E-6 | Longevity |
| THYM | cis | rs11723261 | 1 | rs10021364 | chr4:310691 | ZNF718 | chr4:53272-156488:+ | -0.66 | -6.89 | 6.07E-10 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs9992101 | 1 | rs10023335 | chr4:77358987 | STBD1 | chr4:77172853-77232282:+ | -0.48 | -4.23 | 5.35E-5 | Creatinine levels |
| THYM | cis | rs11723261 | 1 | rs10027325 | chr4:282608 | ZNF718 | chr4:53272-156488:+ | 0.52 | 5.94 | 4.59E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs1109501 | 1 | rs10028351 | chr4:71295971 | AMTN | chr4:71384298-71398459:+ | 0.42 | 4.59 | 1.36E-5 | Alcoholism (heaviness of drinking) |
| THYM | cis | rs10461617 | 1 | rs10051747 | chr5:56083289 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 8.92 | 3.44E-14 | Type 2 diabetes |
| THYM | cis | rs1005224 | 1 | rs1005224 | chr14:76173860 | TTLL5 | chr14:76127621-76421421:+ | 0.33 | 4.35 | 3.48E-5 | Large artery stroke |
| THYM | cis | rs10078 | 1 | rs10078 | chr5:438102 | C5orf55 | chr5:441645-443258:- | 0.37 | 4.77 | 6.74E-6 | Fat distribution (HIV) |
| THYM | cis | rs7849270 | 1 | rs1009242 | chr9:131916832 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs911119 | 1 | rs1010117 | chr20:23608421 | CST9 | chr20:23583049-23586610:- | -0.51 | -4.73 | 7.71E-6 | Chronic kidney disease |
| THYM | cis | rs881375 | 1 | rs10117059 | chr9:123653477 | LOC253039 | chr9:123605320-123616644:+ | -0.62 | -5.56 | 2.51E-7 | Rheumatoid arthritis |